Xeljanz (Tofacitinib) is a medication that belongs to a class of drugs known as Janus kinase (JAK) inhibitors. It works by targeting and blocking certain JAK enzymes, which are involved in the body’s inflammatory response. By inhibiting these enzymes, Xeljanz helps to reduce inflammation and alleviate symptoms associated with autoimmune diseases.
Key Uses:
- Rheumatoid Arthritis: Xeljanz is used to treat moderate to severe rheumatoid arthritis in adults who have not responded adequately to other treatments.
- Psoriatic Arthritis: Xeljanz is used to treat moderate to severe psoriatic arthritis.
- Ulcerative Colitis: Xeljanz is used to treat moderate to severe ulcerative colitis.
- Ankylosing Spondylitis: Xeljanz is used to treat ankylosing spondylitis.
- Juvenile Idiopathic Arthritis: Xeljanz is used to treat polyarticular juvenile idiopathic arthritis in children aged 2 years and older.
How it Works:
- JAK Inhibition: Xeljanz targets and inhibits specific JAK enzymes, including JAK1 and JAK3.
- Reduced Inflammation: By blocking these enzymes, Xeljanz reduces the production of inflammatory cytokines, which play a crucial role in autoimmune diseases.
- Symptom Relief: This reduction in inflammation leads to improved symptoms, such as reduced joint pain, swelling, and stiffness.
Important Considerations:
- Serious Side Effects: Xeljanz can increase the risk of serious infections, heart problems, blood clots, and certain cancers.
- Drug Interactions: Inform your doctor about all medications you are currently taking, including over-the-counter drugs and herbal supplements.
- Pregnancy and Breastfeeding: Consult your doctor before taking Xeljanz if you are pregnant or breastfeeding.
Note: Xeljanz is a prescription medication and should only be used under the supervision of a healthcare professional.
